Biased Ligands. Better Drugs.

TRV130 Journal of Medicinal Chemistry Publication

Structure-Activity Relationships and Discovery of a G Protein Biased Mu Opioid Receptor Ligand, TRV130, for the Treatment of Acute Severe Pain.

Xiao-Tao Chen, Philip Pitis, Guodong Liu, Catherine Yuan, Dimitar Gotchev, Conrad L. Cowan, David H. Rominger, Michael Koblish, Scott M. DeWire, Aimee L. Crombie, Jonathan D. Violin, and Dennis S. Yamashita

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