QuickLinks -- Click here to rapidly navigate through this document


Exhibit 10.33

TREVENA, INC.

FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT

        This First Amendment to Executive Employment Agreement (the "Amendment") is entered into as of January 6, 2016 by and between Trevena, Inc. (the "Company"), a Delaware corporation, and Yacoub Habib ("Executive") and is effective as of January 1, 2016 (the "Effective Date").

        WHEREAS, the Company and the Executive entered into that certain Executive Employment Agreement dated as of July 9, 2015 (the "Original Agreement"); and

        WHEREAS, the Company and the Executive each desire to amend the Original Agreement, as further set forth herein.

        Accordingly, in consideration of the mutual promises and covenants contained herein, the parties agree to the following:


        IN WITNESS WHEREOF, each of the parties has executed this Amendment, in the case of the Company by their duly authorized officers, as of the day and year first above written.

COMPANY:    

TREVENA, INC.

 

 

By:

 

/s/ JOHN M. LIMONGELLI


 

 
    Name:   John M. Limongelli    
    Title:   Senior Vice President, General Counsel & Corporate Secretary    

EXECUTIVE:

 

 

/s/ YACOUB HABIB

Yacoub Habib

 

 

2




QuickLinks

TREVENA, INC. FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT