- Oliceridine (TRV130) Phase 2b postoperative pain study showed compelling profile vs. morphine
- TRV027 AHF Phase 2b trial on track to report top-line data in the second quarter of 2016
- Phase 3 development and NDA filing for oliceridine funded by recent follow-on equity offering
Trevena, Inc. (NASDAQ: TRVN), a clinical stage pharmaceutical company focused on the discovery and development of biased ligands targeting G protein coupled receptors (GPCRs), today announced financial results for the quarter ended September 30, 2015 and provided an update regarding its ongoing clinical programs.
“The third quarter proved transformational for Trevena,” said Maxine Gowen, Ph.D., chief executive officer. “The Phase 2b data we released for oliceridine showed that when given in a clinically relevant administration paradigm for postsurgical pain, oliceridine matched morphine efficacy with significantly less hypoventilation, nausea, and vomiting. The data clearly showed the differentiation Trevena has always aimed for, and highlights the potential of our platform and portfolio.”
Third Quarter and Recent Highlights
Net loss attributable to common stockholders for the quarter ended September 30, 2015 was $10.6 million, or $0.24 per share, compared to $15.5 million, or $0.59 per share for the quarter ended September 30, 2014. Research and development expenses were $9.7 million in the third quarter of 2015 compared to $13.0 million for the same period in 2014, due to timing of clinical trial expenses; general and administrative expenses were $2.8 million, compared to $2.5 million for the third quarter of 2014.
Cash, cash equivalents, and marketable securities totaled $169.0 million as of September 30, 2015, which Trevena expects will be sufficient to fund operations into 2018.
Trevena, Inc. is a clinical stage biopharmaceutical company that discovers, develops and intends to commercialize therapeutics that use a novel approach to target G protein coupled receptors, or GPCRs. Using its proprietary product platform, Trevena is developing four biased ligand product candidates it has identified – TRV027 to treat acute heart failure (Phase 2b), oliceridine (TRV130) to treat moderate to severe acute pain intravenously (completed Phase 2b), TRV734 to treat moderate-to-severe acute and chronic pain orally (Phase 1), and TRV250 migraine and other CNS disorders (preclinical).
Cautionary note on forward-looking statements
Any statements in this press release about future expectations, plans and prospects for the company, including statements about the company’s strategy, future operations, clinical development of its therapeutic candidates, plans for potential future product candidates and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “suggest,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the status, timing, costs, results and interpretation of the company’s clinical trials, including with respect to the potential for future differentiation of oliceridine (TRV130) versus morphine and the timing and status of the BLAST-AHF study of TRV027; the uncertainties inherent in conducting clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or results of early clinical trials will be indicative of the results of future trials, including with respect to earlier studies with oliceridine and expectations for the Phase 3 program; expectations for regulatory approvals; availability of funding sufficient for the company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; other matters that could affect the viability or commercial potential of the company’s therapeutic candidates; the inherent uncertainties associated with intellectual property; and other factors discussed in the Risk Factors set forth in the company’s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings the company makes with the SEC from time to time. In addition, the forward-looking statements included in this press release represent the company’s views only as of the date hereof. The company anticipates that subsequent events and developments may cause the company’s views to change. However, while the company may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, except as may be required by law.
Director, Investor Relations
(610) 354-8840 x231
President and Chief Executive Officer
|Condensed Statements of Operations (Unaudited)|
|Three Months Ended September 30,||Nine Months Ended September 30,|
|General and administrative||2,780,115||2,536,807||8,977,000||7,033,492|
|Research and development||9,650,138||13,006,568||30,524,601||29,671,114|
|Total operating expenses||12,430,253||15,543,375||39,501,601||36,704,606|
|Loss from operations||(10,555,253||)||(15,543,375||)||(35,126,601||)||(36,704,606||)|
|Other income (expense)||(60,230||)||8,503||62,622||300,639|
|Accretion of redeemable convertible preferred stock||-||-||-||(28,521||)|
|Net loss attributable to common stockholders||$||(10,615,483||)||$||(15,534,872||)||$||(35,063,979||)||$||(36,432,488||)|
|Per share information:|
|Net loss per share of common stock, basic and diluted||($0.24||)||($0.59||)||($0.85||)||($1.58||)|
|Weighted average shares outstanding, basic and diluted||44,214,428||26,366,300||41,443,362||23,036,366|
|Condensed Balance Sheets|
|September 30, 2015||December 31, 2014|
|Cash and cash equivalents||$||39,034,709||$||36,205,559|
|Prepaid expenses and other current assets||986,875||669,155|
|Total current assets||169,958,959||107,573,354|
|Property and equipment, net||601,476||553,294|
|Liabilities and stockholders’ equity|
|Accrued expenses and other current liabilities||2,670,607||2,578,269|
|Total current liabilities||10,698,092||6,959,108|
|Loan payable, net||1,777,667||1,692,884|
|Capital lease, net of current portion||8,642||10,677|
|Deferred rent, net of current portion||250,841||281,885|
|Other long term liabilities||40,430||8,025|
|Additional paid-in capital||324,683,788||231,152,894|
|Accumulated other comprehensive income (loss)||42,400||(18,782||)|
|Total stockholders’ equity||157,743,220||99,203,628|
|Total liabilities and stockholders’ equity||$||170,672,845||$||108,239,058|
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