Exhibit 23.1

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Consent of Independent Registered Public Accounting Firm

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We consent to the incorporation by reference in the following Registration Statements:

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1)

Registration Statement (Form S-8 No. 333-193735) pertaining to the 2008 Equity Incentive Plan, the 2013 Equity Incentive plan and the 2013 Employee Stock Purchase Plan of Trevena, Inc.

2)

Registration Statements (Form S-8 Nos. 333-195957, 333-201672, 333-208948, 333-215421, 333-222471, 333-229161, 333-235942, 333-252350, and 333-262377) pertaining to the 2013 Equity Incentive Plan of Trevena, Inc.

3)

Registration Statement (Form S-8 No. 333-215420) pertaining to the Trevena, Inc. Inducement Plan.

4)

Registration Statement (Form S-3 No. 333-225685) of Trevena Inc.

5)

Registration Statement (Form S-3 No. 333-251006) of Trevena Inc.

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of our report dated March 31, 2022, with respect to the financial statements of Trevena, Inc. included in this Annual Report (Form 10-K) of Trevena, Inc. for the year ended December 31, 2021.

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Philadelphia, Pennsylvania

March 31, 2022