Quarterly report pursuant to Section 13 or 15(d)

Stockholders' Equity - Equity Offerings (Details)

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Stockholders' Equity - Equity Offerings (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Dec. 31, 2020
Apr. 30, 2019
Jan. 31, 2019
Stockholders' Equity            
Common stock authorized (in shares) 200,000,000   200,000,000      
Preferred stock authorized (in shares) 5,000,000   5,000,000      
Net proceeds from the offering   $ 2,792        
Warrants outstanding (in shares) 275,430          
Wainwright            
Stockholders' Equity            
Warrants to purchase shares of common stock           500,000
Warrants term           5 years
Exercise price (in dollars per share)           $ 1.25
Warrants outstanding (in shares) 172,500          
At-the-market sales facility - April 17, 2019 agreement | Wainwright | Maximum            
Stockholders' Equity            
Offering amount         $ 50,000  
At-the-market sales facility - December 31, 2020 agreement | Wainwright            
Stockholders' Equity            
Offering amount       $ 50,000    
HCW ATM Program            
Stockholders' Equity            
Net proceeds from the offering $ 0          
Stock available for further issuance $ 41,900