Quarterly report pursuant to Section 13 or 15(d)

Stockholder's Equity - Shares Reserved for Future Grant and Issuance (Details)

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Stockholder's Equity - Shares Reserved for Future Grant and Issuance (Details) - shares
 3 Months Ended
Dec. 15, 2016
Mar. 31, 2022
Dec. 31, 2021
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   12,259,011 12,449,870
Warrants outstanding (in shares)   275,430  
Total shares of common stock reserved for future issuance (in shares)   18,931,243  
2013 plan      
Shares Available for Future Grant      
Balance at the beginning of the period (in shares)   4,178,805  
Authorized (in shares)   6,620,800  
Granted (in shares)   (244,950)  
Forfeited/Cancelled (in shares)   27,871  
Balance at the end of the period (in shares)   10,582,526  
Shares Reserved for Future Issuance      
Shares available for future issuance (in shares)   10,582,526 4,178,805
Inducement Plan      
Shares Available for Future Grant      
Balance at the beginning of the period (in shares)   252,500  
Authorized (in shares) 500,000    
Balance at the end of the period (in shares)   252,500  
Shares Reserved for Future Issuance      
Shares available for future issuance (in shares)   252,500 252,500
2013 Employee Stock Purchase Plan      
Shares Available for Future Grant      
Balance at the end of the period (in shares)   225,806  
Shares Reserved for Future Issuance      
Shares available for future issuance (in shares)   225,806  
Employee Stock Option | 2013 plan      
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   12,011,511  
Employee Stock Option | Inducement Plan      
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   247,500  
Restricted Stock Units | 2013 plan      
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   5,918,496