Biased Ligands. Better Drugs.

TRV130 efficacy and tolerability in rodents

A G protein biased mu opioid receptor ligand elicits potent analgesia but reduced constipation & respiratory depression compared to morphine in rodents. Presented at the 2012 American Association of Pain Medicine Meeting

Soergel DG, Violin JD, DeWire SD, LaBuda CJ, Yamashita D, Lark MW

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