Biased Ligands. Better Drugs.

TRV130 Phase 1b full results

Biased agonism of the mu-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain 155(9):1829-35, September 2014.

David G. Soergel, Ruth Ann Subach, Nancy Burnham, Michael W. Lark, Ian E. James, Brian M. Sadler, Franck Skobieranda, Jonathan D. Violin, Lynn R. Webster

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