Quarterly report pursuant to Section 13 or 15(d)

Stockholder's Equity - Shares Reserved for Future Grant Issuance (Details)

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Stockholder's Equity - Shares Reserved for Future Grant Issuance (Details) - shares
9 Months Ended
Sep. 30, 2019
Sep. 30, 2019
Dec. 31, 2018
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   7,678,421 8,265,207
Warrants outstanding (in shares)   623,091  
Total shares of common stock reserved for issuance (in shares)   16,151,943  
2013 plan      
Shares Available for Future Grant      
Balance at the beginning of the period (in shares) 2,603,983    
Authorized (in shares) 3,387,456    
Granted (in shares) (1,363,000)    
Forfeitures/Expirations (in shares) 1,781,030    
Balance at the end of the period (in shares) 6,409,469    
Shares Reserved for Future Issuance      
Shares available for future grant (in shares) 2,603,983 6,409,469 2,603,983
Inducement Plan      
Shares Available for Future Grant      
Balance at the beginning of the period (in shares) 144,125    
Forfeitures/Expirations (in shares) 46,031    
Balance at the end of the period (in shares) 190,156    
Shares Reserved for Future Issuance      
Shares available for future grant (in shares) 144,125 190,156 144,125
Employee Stock Purchase Plan [Member]      
Shares Reserved for Future Issuance      
Total shares of common stock reserved for issuance (in shares)   225,806  
Employee Stock Option | 2013 plan      
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   7,368,577  
Employee Stock Option | Inducement Plan      
Shares Reserved for Future Issuance      
Stock options outstanding (in shares)   309,844  
Restricted Stock Units | 2013 plan      
Shares Reserved for Future Issuance      
Total shares of common stock reserved for issuance (in shares)   1,025,000